If you have manually moved the distributor it could be far enough off to not run, try moving it a little in each direction while cranking the engine to see if it starts up, then move it and tune by ear to see if you can get it to idle, then bust out your timing light and time it correctly.
Also set the idle screw on your carb to the baseline (like 1 1/2 - 2 turns out) to get it running, after the timing is set you can start to tune your carb, you may need to make some changes to the jets.
Also make sure there are no vacuum leaks, your car will never run right with a vacuum leak.
Here are some instructions on tuning a weber carb: http://www.carburetion.com/Weber/adjust.htm