You said that the injector opens at 425psi but you didn’t say how you tested it? If you swapped the injectors and #1 is still a problem I suspect the pump is not delivering the same amount of fuel to #1 as it is to the other cylinders. The #1 piston in the pump may be sticking, the #1 inlet valve in the pump might be sticking ( open OR closed!).
Does it idle like there is a dead cylinder but then run ok under load? If so go back and check for a vacuum leak as previously recommended. If it is dead under load as well again try new plugs and wires. Look carefully at the cap, make sure the contacts are good and there are no cracks.