I had mine loosen a number of times and re-tightened them, and/or swapped bolts. If the guibo looks fine its probably better not to mess with it and screw more stuff up. The guibo only starts shredding itself after you lose a couple bolts. If you don't get bolts super tight, they wiggle out, independent of guibo status. I use red loc-tite and tighten the hell out of them now.
Use OEM bolts and OEM locking nuts, they're not nylocks. The OEMs are all metal and special to dig in tight. Nylocks aren't great for a second use, if you have to do that. I usually hit nylocs with a torch to melt it a little for a re-use, but figure it's not quite as good as they were new.
And yeah, there's a proper pattern and direction for the bolts, I forget the details.
And sure, many cars can get away with using cheapo nylocks barely tightened, and it works fine for years. That's because they may have everything well balanced and aligned perfectly. If stuff isn't quite perfect, those bolts loosen up. I used every method and tool to try to align my driveshaft, but still guibo bolts would get loose if I didn't loc-tite and tighten the holy hell out of them.
I eventually remedied my problem by switching to a 5-speed with a better 6 bolt guibo.
For your purposes though for the drive, I'd just loc-tite or upgrade hardware as you can, and tighten the holy hell out of each bolt, and check on them periodically.